Adjuvants and Immunization Strategies to Induce Influenza Virus Hemagglutinin Stalk Antibodies
Identifieur interne : 000918 ( Main/Exploration ); précédent : 000917; suivant : 000919Adjuvants and Immunization Strategies to Induce Influenza Virus Hemagglutinin Stalk Antibodies
Auteurs : Peter H. Goff [États-Unis] ; Dirk Eggink [États-Unis] ; Christopher W. Seibert [États-Unis] ; Rong Hai [États-Unis] ; Luis Martínez-Gil [États-Unis] ; Florian Krammer [États-Unis] ; Peter Palese [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
The global population remains vulnerable in the face of the next pandemic influenza virus outbreak, and reformulated vaccinations are administered annually to manage seasonal epidemics. Therefore, development of a new generation of vaccines is needed to generate broad and persistent immunity to influenza viruses. Here, we describe three adjuvants that enhance the induction of stalk-directed antibodies against heterologous and heterosubtypic influenza viruses when administered with chimeric HA proteins. Addavax, an MF59-like nanoemulsion, poly(I:C), and an RNA hairpin derived from Sendai virus (SeV) Cantell were efficacious intramuscularly. The SeV RNA and poly(I:C) also proved to be effective respiratory mucosal adjuvants. Although the quantity and quality of antibodies induced by the adjuvants varied, immunized mice demonstrated comparable levels of protection against challenge with influenza A viruses on the basis of HA stalk reactivity. Finally, we present that intranasally, but not intramuscularly, administered chimeric HA proteins induce mucosal IgA antibodies directed at the HA stalk.
Url:
DOI: 10.1371/journal.pone.0079194
PubMed: 24223176
PubMed Central: 3819267
Affiliations:
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Therefore, development of a new generation of vaccines is needed to generate broad and persistent immunity to influenza viruses. Here, we describe three adjuvants that enhance the induction of stalk-directed antibodies against heterologous and heterosubtypic influenza viruses when administered with chimeric HA proteins. Addavax, an MF59-like nanoemulsion, poly(I:C), and an RNA hairpin derived from Sendai virus (SeV) Cantell were efficacious intramuscularly. The SeV RNA and poly(I:C) also proved to be effective respiratory mucosal adjuvants. Although the quantity and quality of antibodies induced by the adjuvants varied, immunized mice demonstrated comparable levels of protection against challenge with influenza A viruses on the basis of HA stalk reactivity. Finally, we present that intranasally, but not intramuscularly, administered chimeric HA proteins induce mucosal IgA antibodies directed at the HA stalk.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smith, Gjd" uniqKey="Smith G">GJD Smith</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Shaw, M" uniqKey="Shaw M">M Shaw</name></author><author><name sortKey="Wright, P" uniqKey="Wright P">P Wright</name></author><author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name></author><author><name 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Koutsonanos</name></author><author><name sortKey="Li, G M" uniqKey="Li G">G-M Li</name></author><author><name sortKey="Edupuganti, S" uniqKey="Edupuganti S">S Edupuganti</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Ms" uniqKey="Miller M">MS Miller</name></author><author><name sortKey="Tsibane, T" uniqKey="Tsibane T">T Tsibane</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name></author><author><name sortKey="Rahmat, S" uniqKey="Rahmat S">S Rahmat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wrammert, J" uniqKey="Wrammert J">J Wrammert</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K Smith</name></author><author><name sortKey="Miller, J" uniqKey="Miller J">J Miller</name></author><author><name sortKey="Langley, Wa" uniqKey="Langley W">WA Langley</name></author><author><name sortKey="Kokko, K" uniqKey="Kokko K">K Kokko</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Goff, Peter H" sort="Goff, Peter H" uniqKey="Goff P" first="Peter H." last="Goff">Peter H. Goff</name></region><name sortKey="Eggink, Dirk" sort="Eggink, Dirk" uniqKey="Eggink D" first="Dirk" last="Eggink">Dirk Eggink</name><name sortKey="Goff, Peter H" sort="Goff, Peter H" uniqKey="Goff P" first="Peter H." last="Goff">Peter H. Goff</name><name sortKey="Hai, Rong" sort="Hai, Rong" uniqKey="Hai R" first="Rong" last="Hai">Rong Hai</name><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><name sortKey="Martinez Gil, Luis" sort="Martinez Gil, Luis" uniqKey="Martinez Gil L" first="Luis" last="Martínez-Gil">Luis Martínez-Gil</name><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name><name sortKey="Seibert, Christopher W" sort="Seibert, Christopher W" uniqKey="Seibert C" first="Christopher W." last="Seibert">Christopher W. Seibert</name><name sortKey="Seibert, Christopher W" sort="Seibert, Christopher W" uniqKey="Seibert C" first="Christopher W." last="Seibert">Christopher W. Seibert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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